4iqy

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==Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2==
==Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2==
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<StructureSection load='4iqy' size='340' side='right' caption='[[4iqy]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4iqy' size='340' side='right'caption='[[4iqy]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iqy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MACROD2, C20orf133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqy RCSB], [http://www.ebi.ac.uk/pdbsum/4iqy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqy OCA], [https://pdbe.org/4iqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqy RCSB], [https://www.ebi.ac.uk/pdbsum/4iqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MACD2_HUMAN MACD2_HUMAN]] Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.<ref>PMID:21257746</ref>
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[https://www.uniprot.org/uniprot/MACD2_HUMAN MACD2_HUMAN] Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.<ref>PMID:21257746</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4iqy" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Golia, B]]
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[[Category: Large Structures]]
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[[Category: Hassler, M]]
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[[Category: Golia B]]
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[[Category: Jankevicius, G]]
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[[Category: Hassler M]]
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[[Category: Ladurner, A G]]
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[[Category: Jankevicius G]]
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[[Category: Rybin, V]]
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[[Category: Ladurner AG]]
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[[Category: Timinszky, G]]
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[[Category: Rybin V]]
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[[Category: Zacharias, M]]
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[[Category: Timinszky G]]
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[[Category: Adp-ribose binding]]
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[[Category: Zacharias M]]
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[[Category: Adp-ribosylation]]
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[[Category: Hydrolase]]
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[[Category: Macrodomain]]
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[[Category: Nuclear/cytoplasmic]]
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Current revision

Crystal structure of the human protein-proximal ADP-ribosyl-hydrolase MacroD2

PDB ID 4iqy

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