2xrb
From Proteopedia
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==Structure of the N-terminal four domains of the complement regulator Rat Crry== | ==Structure of the N-terminal four domains of the complement regulator Rat Crry== | ||
| - | <StructureSection load='2xrb' size='340' side='right' caption='[[2xrb]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='2xrb' size='340' side='right'caption='[[2xrb]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xrb]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRB FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrb OCA], [https://pdbe.org/2xrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrb RCSB], [https://www.ebi.ac.uk/pdbsum/2xrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrb ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CR1L_RAT CR1L_RAT] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.<ref>PMID:15474557</ref> <ref>PMID:7534798</ref> <ref>PMID:8144902</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2xrb" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Johnson | + | [[Category: Johnson S]] |
| - | [[Category: Lea | + | [[Category: Lea SM]] |
| - | [[Category: Leath | + | [[Category: Leath KJ]] |
| - | [[Category: Morgan | + | [[Category: Morgan BP]] |
| - | [[Category: Roversi | + | [[Category: Roversi P]] |
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Current revision
Structure of the N-terminal four domains of the complement regulator Rat Crry
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