1yj5
From Proteopedia
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==Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme== | ==Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme== | ||
| - | <StructureSection load='1yj5' size='340' side='right' caption='[[1yj5]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='1yj5' size='340' side='right'caption='[[1yj5]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YJ5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yj5 OCA], [https://pdbe.org/1yj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yj5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yj/1yj5_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yj/1yj5_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yj5 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1yj5" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Bernstein NK]] | |
| - | [[Category: Bernstein | + | [[Category: Cass CE]] |
| - | [[Category: Cass | + | [[Category: Cui D]] |
| - | [[Category: Cui | + | [[Category: Durocher D]] |
| - | [[Category: Durocher | + | [[Category: Galicia S]] |
| - | [[Category: Galicia | + | [[Category: Glover JNM]] |
| - | [[Category: Glover | + | [[Category: Green R]] |
| - | [[Category: Green | + | [[Category: Karimi-Busheri F]] |
| - | [[Category: Karimi-Busheri | + | [[Category: Koch CA]] |
| - | [[Category: Koch | + | [[Category: Mani RS]] |
| - | [[Category: Mani | + | [[Category: Rakovszky ML]] |
| - | [[Category: Rakovszky | + | [[Category: Weinfeld M]] |
| - | [[Category: Weinfeld | + | [[Category: Williams RS]] |
| - | [[Category: Williams | + | |
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Current revision
Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme
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Categories: Large Structures | Mus musculus | Bernstein NK | Cass CE | Cui D | Durocher D | Galicia S | Glover JNM | Green R | Karimi-Busheri F | Koch CA | Mani RS | Rakovszky ML | Weinfeld M | Williams RS
