2ec7

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[[Image:2ec7.jpg|left|200px]]
 
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{{Structure
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==Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein==
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|PDB= 2ec7 |SIZE=350|CAPTION= <scene name='initialview01'>2ec7</scene>
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<StructureSection load='2ec7' size='340' side='right'caption='[[2ec7]]' scene=''>
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+50'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+51'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2ec7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_GHANA-1) Human immunodeficiency virus type 2 (ISOLATE GHANA-1)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec7 OCA], [https://pdbe.org/2ec7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_HV2G1 GAG_HV2G1] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec7 ConSurf].
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<div style="clear:both"></div>
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'''Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein'''
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==See Also==
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2EC7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA].
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[[Category: Large Structures]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Endoh H]]
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[[Category: Single protein]]
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[[Category: Kodera Y]]
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[[Category: Endoh, H.]]
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[[Category: Kohno T]]
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[[Category: Kodera, Y.]]
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[[Category: Komatsu H]]
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[[Category: Kohno, T.]]
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[[Category: Maeda T]]
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[[Category: Komatsu, H.]]
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[[Category: Matsui T]]
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[[Category: Maeda, T.]]
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[[Category: Miyauchi E]]
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[[Category: Matsui, T.]]
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[[Category: Tanaka H]]
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[[Category: Miyauchi, E.]]
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[[Category: Tanaka T]]
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[[Category: Tanaka, H.]]
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[[Category: Tanaka, T.]]
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[[Category: ZN]]
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[[Category: hiv-2]]
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[[Category: nucleocapsid protein]]
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[[Category: rna recognition]]
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[[Category: viral protein]]
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[[Category: zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:38:07 2008''
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Current revision

Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein

PDB ID 2ec7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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