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4bij

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==Threading model of T7 large terminase==
==Threading model of T7 large terminase==
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<StructureSection load='4bij' size='340' side='right' caption='[[4bij]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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<SX load='4bij' size='340' side='right' viewer='molstar' caption='[[4bij]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bij]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bij]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIJ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bil|4bil]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bij RCSB], [http://www.ebi.ac.uk/pdbsum/4bij PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bij OCA], [https://pdbe.org/4bij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bij RCSB], [https://www.ebi.ac.uk/pdbsum/4bij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bij ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VDMB_BPT7 VDMB_BPT7]] During the growth of this phage, DNA is synthesized as concatemers. During DNA packaging mature monomers are cut from the concatemers. Gp19 is a nonspecific endonuclease that cause double stranded breaks. Its activity is suppressible by either ATP or gp18.
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[https://www.uniprot.org/uniprot/TERL_BPT7 TERL_BPT7] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome at a unique and precise dsDNA sequence to initiate and to end a packaging reaction (By similarity). The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities (By similarity). Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine (PubMed:23632014). The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer (By similarity). Once the DNA is packaged, the terminase detaches from the portal and gets replaced by the tail to finish maturation of the virion (PubMed:23632014).[HAMAP-Rule:MF_04147]<ref>PMID:23632014</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bij" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Terminase 3D Structures|Terminase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Enterobacteria phage t7]]
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[[Category: Escherichia phage T7]]
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[[Category: Carrascosa, J L]]
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[[Category: Large Structures]]
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[[Category: Dauden, M I]]
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[[Category: Carrascosa JL]]
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[[Category: Martin-Benito, J]]
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[[Category: Dauden MI]]
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[[Category: Pulido-Cid, M]]
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[[Category: Martin-Benito J]]
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[[Category: Sanchez-Ferrero, J C]]
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[[Category: Pulido-Cid M]]
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[[Category: Valpuesta, J M]]
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[[Category: Sanchez-Ferrero JC]]
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[[Category: Atpase]]
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[[Category: Valpuesta JM]]
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[[Category: Dna translocation]]
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[[Category: Hydrolase]]
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[[Category: Single-particle reconstruction]]
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Current revision

Threading model of T7 large terminase

4bij, resolution 16.00Å

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