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3tua

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==Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1) C94S mutant==
==Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1) C94S mutant==
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<StructureSection load='3tua' size='340' side='right' caption='[[3tua]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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<StructureSection load='3tua' size='340' side='right'caption='[[3tua]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tua]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TUA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tu8|3tu8]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BPSL1549 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tua OCA], [https://pdbe.org/3tua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tua RCSB], [https://www.ebi.ac.uk/pdbsum/3tua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tua ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tua RCSB], [http://www.ebi.ac.uk/pdbsum/3tua PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q63UP7_BURPS Q63UP7_BURPS]
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The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.
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A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.,Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW Science. 2011 Nov 11;334(6057):821-4. PMID:22076380<ref>PMID:22076380</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Artymiuk, P J]]
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[[Category: Large Structures]]
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[[Category: Baker, P J]]
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[[Category: Artymiuk PJ]]
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[[Category: Chang, C T]]
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[[Category: Baker PJ]]
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[[Category: Cruz, A]]
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[[Category: Chang CT]]
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[[Category: Hautbergue, G M]]
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[[Category: Cruz A]]
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[[Category: Mahadi, N M]]
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[[Category: Hautbergue GM]]
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[[Category: Mobbs, G W]]
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[[Category: Mahadi NM]]
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[[Category: Mohamed, R]]
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[[Category: Mobbs GW]]
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[[Category: Nathan, S]]
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[[Category: Mohamed R]]
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[[Category: Partridge, L J]]
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[[Category: Nathan S]]
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[[Category: Raih, M F]]
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[[Category: Partridge LJ]]
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[[Category: Rice, D W]]
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[[Category: Raih MF]]
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[[Category: Ruzheinikov, S N]]
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[[Category: Rice DW]]
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[[Category: Sedelnikova, S E]]
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[[Category: Ruzheinikov SN]]
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[[Category: Wilson, S A]]
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[[Category: Sedelnikova SE]]
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[[Category: Toxin]]
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[[Category: Wilson SA]]
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[[Category: Unknown function]]
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Current revision

Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1) C94S mutant

PDB ID 3tua

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