3qlv

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==Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD tetramer assembly==
==Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD tetramer assembly==
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<StructureSection load='3qlv' size='340' side='right' caption='[[3qlv]], [[Resolution|resolution]] 3.94&Aring;' scene=''>
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<StructureSection load='3qlv' size='340' side='right'caption='[[3qlv]], [[Resolution|resolution]] 3.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qlv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QLV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qlv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLV FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qlu|3qlu]], [[3qlt|3qlt]], [[3om0|3om0]], [[3h6g|3h6g]], [[3olz|3olz]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.94&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grik5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Glur6, Grik2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlv OCA], [https://pdbe.org/3qlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlv RCSB], [https://www.ebi.ac.uk/pdbsum/3qlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qlv RCSB], [http://www.ebi.ac.uk/pdbsum/3qlv PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
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[https://www.uniprot.org/uniprot/GRIK5_RAT GRIK5_RAT] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3qlv" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Kumar, J]]
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[[Category: Kumar J]]
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[[Category: Mayer, M L]]
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[[Category: Mayer ML]]
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[[Category: Glycosylation]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD tetramer assembly

PDB ID 3qlv

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