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| - | ==Crystal structure of human mitogen activated protein kinase 6 (MAPK6)==
| + | #REDIRECT [[7aqb]] This PDB entry is obsolete and replaced by 7aqb |
| - | <StructureSection load='2i6l' size='340' side='right' caption='[[2i6l]], [[Resolution|resolution]] 2.25Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[2i6l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I6L FirstGlance]. <br>
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| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPK6, ERK3, PRKM6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i6l RCSB], [http://www.ebi.ac.uk/pdbsum/2i6l PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/MK06_HUMAN MK06_HUMAN]] Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
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| - | == Evolutionary Conservation ==
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| - | [[Image:Consurf_key_small.gif|200px|right]]
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| - | Check<jmol>
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| - | <jmolCheckbox>
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| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6l_consurf.spt"</scriptWhenChecked>
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| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| - | <text>to colour the structure by Evolutionary Conservation</text>
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| - | </jmolCheckbox>
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| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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| - | <div style="clear:both"></div>
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| - | ==See Also==
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| - | *[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Mitogen-activated protein kinase]]
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| - | [[Category: Arrowsmith, C]]
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| - | [[Category: Berridge, G]]
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| - | [[Category: Bunkonczi, G]]
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| - | [[Category: Das, S]]
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| - | [[Category: Debreczeni, J]]
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| - | [[Category: Delft, F von]]
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| - | [[Category: Doyle, D]]
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| - | [[Category: Edwards, A]]
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| - | [[Category: Elkins, J]]
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| - | [[Category: Fedorov, O]]
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| - | [[Category: Filippakopoulos, P]]
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| - | [[Category: Knapp, S]]
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| - | [[Category: Papagrigoriou, E]]
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| - | [[Category: Pike, A C.W]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Savitsky, P]]
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| - | [[Category: Soundararajan, M]]
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| - | [[Category: Sundstrom, M]]
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| - | [[Category: Turnbull, A P]]
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| - | [[Category: Ugochukwu, E]]
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| - | [[Category: Yang, X W]]
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| - | [[Category: Erk3]]
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| - | [[Category: Extracellular signal regulated kinase 3]]
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| - | [[Category: Mapk6]]
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| - | [[Category: Mitogen activated protein kinase 6]]
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| - | [[Category: Serine phosphorylation]]
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| - | [[Category: Sgc]]
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| - | [[Category: Threonine phosphorylation]]
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| - | [[Category: Transferase]]
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