This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4mll

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:39, 20 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==
==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==
-
<StructureSection load='4mll' size='340' side='right' caption='[[4mll]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
+
<StructureSection load='4mll' size='340' side='right'caption='[[4mll]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MLL FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MLL FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f94|4f94]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla, bla oxa1, oxa1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [https://pdbe.org/4mll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [https://www.ebi.ac.uk/pdbsum/4mll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [http://www.ebi.ac.uk/pdbsum/4mll PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX]] This is an oxacillin-hydrolyzing beta-lactamase.
+
[https://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX] This is an oxacillin-hydrolyzing beta-lactamase.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4mll" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Beta-lactamase|Beta-lactamase]]
+
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus coli migula 1895]]
+
[[Category: Escherichia coli]]
-
[[Category: Beta-lactamase]]
+
[[Category: Large Structures]]
-
[[Category: Bonomo, R A]]
+
[[Category: Bonomo RA]]
-
[[Category: June, C M]]
+
[[Category: June CM]]
-
[[Category: Leonard, D A]]
+
[[Category: Leonard DA]]
-
[[Category: Powers, R A]]
+
[[Category: Powers RA]]
-
[[Category: Vallier, B C]]
+
[[Category: Vallier BC]]
-
[[Category: Antibiotic resistance]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-antibiotic complex]]
+
-
[[Category: Oxacillinase]]
+

Current revision

The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin

PDB ID 4mll

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mll"
Personal tools