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4u0o

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==Crystal structure of Thermosynechococcus elongatus Lipoyl Synthase 2 complexed with MTA and DTT==
==Crystal structure of Thermosynechococcus elongatus Lipoyl Synthase 2 complexed with MTA and DTT==
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<StructureSection load='4u0o' size='340' side='right' caption='[[4u0o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='4u0o' size='340' side='right'caption='[[4u0o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u0o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U0O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U0O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoyl_synthase Lipoyl synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.8 2.8.1.8] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u0o RCSB], [http://www.ebi.ac.uk/pdbsum/4u0o PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u0o OCA], [https://pdbe.org/4u0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u0o RCSB], [https://www.ebi.ac.uk/pdbsum/4u0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u0o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LIPA2_THEEB LIPA2_THEEB]] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).
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[https://www.uniprot.org/uniprot/LIPA2_THEVB LIPA2_THEVB] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.[HAMAP-Rule:MF_00206]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4u0o" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lipoyl synthase]]
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[[Category: Large Structures]]
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[[Category: Dinis, P C]]
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[[Category: Thermosynechococcus vestitus BP-1]]
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[[Category: Harmer, J E]]
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[[Category: Dinis PC]]
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[[Category: Hiscox, M J]]
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[[Category: Harmer JE]]
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[[Category: Roach, P L]]
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[[Category: Hiscox MJ]]
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[[Category: Sandy, J]]
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[[Category: Roach PL]]
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[[Category: Radical sam]]
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[[Category: Sandy J]]
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[[Category: Sulfotransferase]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Thermosynechococcus elongatus Lipoyl Synthase 2 complexed with MTA and DTT

PDB ID 4u0o

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