2yly
From Proteopedia
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==Sulfonamides as selective Estrogen Receptor beta Agonists.== | ==Sulfonamides as selective Estrogen Receptor beta Agonists.== | ||
| - | <StructureSection load='2yly' size='340' side='right' caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2yly" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Estrogen receptor|Estrogen receptor]] | + | *[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Armour | + | [[Category: Large Structures]] |
| - | [[Category: Barker | + | [[Category: Armour D]] |
| - | [[Category: Bazin | + | [[Category: Barker C]] |
| - | [[Category: Bess | + | [[Category: Bazin R]] |
| - | [[Category: Brown | + | [[Category: Bess K]] |
| - | [[Category: Ellis | + | [[Category: Brown A]] |
| - | [[Category: Favor | + | [[Category: Ellis D]] |
| - | [[Category: | + | [[Category: Favor D]] |
| - | [[Category: Phillips | + | [[Category: MacKenny M]] |
| - | [[Category: Pullen | + | [[Category: Phillips C]] |
| - | [[Category: Roberts | + | [[Category: Pullen N]] |
| - | [[Category: Stennett | + | [[Category: Roberts LR]] |
| - | [[Category: Strand | + | [[Category: Stennett A]] |
| - | [[Category: Styles | + | [[Category: Strand L]] |
| - | + | [[Category: Styles M]] | |
Current revision
Sulfonamides as selective Estrogen Receptor beta Agonists.
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Categories: Homo sapiens | Large Structures | Armour D | Barker C | Bazin R | Bess K | Brown A | Ellis D | Favor D | MacKenny M | Phillips C | Pullen N | Roberts LR | Stennett A | Strand L | Styles M
