4twk

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==Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)==
==Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)==
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<StructureSection load='4twk' size='340' side='right' caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4twk' size='340' side='right'caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [https://pdbe.org/4twk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [https://www.ebi.ac.uk/pdbsum/4twk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN]] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref> Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
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[https://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref> Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ang, J H]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Berridge, G]]
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[[Category: Ang JH]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Berridge G]]
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[[Category: Bushell, S R]]
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[[Category: Bountra C]]
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[[Category: Carpenter, E P]]
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[[Category: Burgess-Brown NA]]
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[[Category: Chalk, R]]
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[[Category: Bushell SR]]
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[[Category: Chu, A]]
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[[Category: Carpenter EP]]
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[[Category: Delft, F von]]
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[[Category: Chalk R]]
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[[Category: Dong, L]]
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[[Category: Chu A]]
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[[Category: Dong, Y Y]]
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[[Category: Dong L]]
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[[Category: Edwards, A M]]
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[[Category: Dong YY]]
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[[Category: Faust, B]]
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[[Category: Edwards AM]]
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[[Category: Goubin, S]]
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[[Category: Faust B]]
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[[Category: Grieben, M]]
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[[Category: Goubin S]]
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[[Category: Kupinska, K]]
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[[Category: Grieben M]]
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[[Category: Mackenzie, A]]
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[[Category: Kupinska K]]
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[[Category: Mukhopadhyay, S]]
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[[Category: Mackenzie A]]
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[[Category: Pike, A C.W]]
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[[Category: Mukhopadhyay S]]
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[[Category: Quigley, A]]
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[[Category: Pike ACW]]
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[[Category: Shintre, C A]]
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[[Category: Quigley A]]
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[[Category: Shrestha, L]]
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[[Category: Shintre CA]]
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[[Category: Strain-Damerell, C]]
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[[Category: Shrestha L]]
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[[Category: Tessitore, A]]
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[[Category: Strain-Damerell C]]
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[[Category: Wang, D]]
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[[Category: Tessitore A]]
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[[Category: Ion channel]]
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[[Category: Wang D]]
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[[Category: K2p]]
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[[Category: Von Delft F]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

PDB ID 4twk

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