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3mj0
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==Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA== | ==Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA== | ||
| - | <StructureSection load='3mj0' size='340' side='right' caption='[[3mj0]], [[Resolution|resolution]] 2.31Å' scene=''> | + | <StructureSection load='3mj0' size='340' side='right'caption='[[3mj0]], [[Resolution|resolution]] 2.31Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3mj0]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3mj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJ0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.306Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mj0 OCA], [https://pdbe.org/3mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mj0 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref> |
==See Also== | ==See Also== | ||
| - | *[[Argonaute|Argonaute]] | + | *[[Argonaute 3D structures|Argonaute 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ding L]] |
| - | [[Category: | + | [[Category: Huang Y]] |
| - | [[Category: | + | [[Category: Ma J]] |
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Current revision
Crystal Structure of Drosophia Ago-PAZ domain in complex with 3'-end 2'-O-methylated RNA
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