This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ek2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:51, 29 May 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ek2.jpg|left|200px]]
 
-
{{Structure
+
==Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (E140M)==
-
|PDB= 2ek2 |SIZE=350|CAPTION= <scene name='initialview01'>2ek2</scene>, resolution 2.20&Aring;
+
<StructureSection load='2ek2' size='340' side='right'caption='[[2ek2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
+
<table><tr><td colspan='2'>[[2ek2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EK2 FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ek2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ek2 OCA], [https://pdbe.org/2ek2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ek2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ek2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ek2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ek2 TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/2ek2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ek2 ConSurf].
 +
<div style="clear:both"></div>
-
'''Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (E140M)'''
+
==See Also==
-
 
+
*[[Diphthine synthase|Diphthine synthase]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2EK2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EK2 OCA].
+
__TOC__
-
[[Category: Diphthine synthase]]
+
</StructureSection>
-
[[Category: Pyrococcus horikoshii]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Pyrococcus horikoshii OT3]]
-
[[Category: Asada, Y.]]
+
[[Category: Asada Y]]
-
[[Category: Kunishima, N.]]
+
[[Category: Kunishima N]]
-
[[Category: Matsuura, Y.]]
+
[[Category: Matsuura Y]]
-
[[Category: Nakamoto, T.]]
+
[[Category: Nakamoto T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Tanaka Y]]
-
[[Category: Tanaka, Y.]]
+
-
[[Category: NA]]
+
-
[[Category: SAH]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: nppsfa]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
[[Category: transferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:41:16 2008''
+

Current revision

Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (E140M)

PDB ID 2ek2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ek2"
Personal tools