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| | ==Crystal structure of SYCE3== | | ==Crystal structure of SYCE3== |
| - | <StructureSection load='4r3q' size='340' side='right' caption='[[4r3q]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='4r3q' size='340' side='right'caption='[[4r3q]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [http://www.ebi.ac.uk/pdbsum/4r3q PDBsum]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [https://pdbe.org/4r3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [https://www.ebi.ac.uk/pdbsum/4r3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3q ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE]] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> | + | [https://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> |
| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements.
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| - | Structural insight into the central element assembly of the synaptonemal complex.,Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919<ref>PMID:25394919</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Feng, J]] | + | [[Category: Large Structures]] |
| - | [[Category: Lu, J]] | + | [[Category: Mus musculus]] |
| - | [[Category: Shen, Y]] | + | [[Category: Feng J]] |
| - | [[Category: Yang, X]] | + | [[Category: Lu J]] |
| - | [[Category: Zhou, W]] | + | [[Category: Shen Y]] |
| - | [[Category: Cell cycle]] | + | [[Category: Yang X]] |
| - | [[Category: Coiled-coil]] | + | [[Category: Zhou W]] |
| - | [[Category: Synaptonemal complex]]
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| Structural highlights
Function
SYCE3_MOUSE Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.[1] [2]
References
- ↑ Hu T, Wang Z, Zeng F, Chen X, Gu Z, Zheng L, Tong Q. Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells. J Huazhong Univ Sci Technolog Med Sci. 2010 Apr;30(2):193-7. doi:, 10.1007/s11596-010-0212-3. Epub 2010 Apr 21. PMID:20407872 doi:http://dx.doi.org/10.1007/s11596-010-0212-3
- ↑ Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Hoog C, Cooke HJ, Alsheimer M, Benavente R. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. PLoS Genet. 2011 May;7(5):e1002088. doi: 10.1371/journal.pgen.1002088. Epub 2011 , May 26. PMID:21637789 doi:http://dx.doi.org/10.1371/journal.pgen.1002088
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