2ela

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[[Image:2ela.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the PTB domain of human APPL1==
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|PDB= 2ela |SIZE=350|CAPTION= <scene name='initialview01'>2ela</scene>, resolution 2.0&Aring;
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<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [https://pdbe.org/2ela PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [https://www.ebi.ac.uk/pdbsum/2ela PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Crystal Structure of the PTB domain of human APPL1'''
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[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2ela_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2ELA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ela ConSurf].
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Crystal structures of the BAR-PH and PTB domains of human APPL1., Li J, Mao X, Dong LQ, Liu F, Tong L, Structure. 2007 May;15(5):525-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17502098 17502098]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dong, L Q.]]
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[[Category: Dong LQ]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Liu, F.]]
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[[Category: Liu F]]
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[[Category: Mao, X.]]
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[[Category: Mao X]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: appl]]
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[[Category: ptb domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:41:39 2008''
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Current revision

Crystal Structure of the PTB domain of human APPL1

PDB ID 2ela

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OCA

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