3pz8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:09, 1 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of Dvl1-DIX(Y17D) mutant==
==Crystal structure of Dvl1-DIX(Y17D) mutant==
-
<StructureSection load='3pz8' size='340' side='right' caption='[[3pz8]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
+
<StructureSection load='3pz8' size='340' side='right'caption='[[3pz8]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dvl1, Dvl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.873&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pz8 PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [https://pdbe.org/3pz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
+
[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Chen, L]]
+
[[Category: Chen L]]
-
[[Category: Dan, Q J]]
+
[[Category: Dan QJ]]
-
[[Category: Liu, Y T]]
+
[[Category: Liu YT]]
-
[[Category: Wu, J W]]
+
[[Category: Wu JW]]
-
[[Category: Zhang, Y Y]]
+
[[Category: Zhang YY]]
-
[[Category: Dix domain]]
+
-
[[Category: Oligomerization]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal structure of Dvl1-DIX(Y17D) mutant

PDB ID 3pz8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3pz8"
Personal tools