4fz5
From Proteopedia
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==Crystal Structure of Human TIRAP TIR-domain== | ==Crystal Structure of Human TIRAP TIR-domain== | ||
| - | <StructureSection load='4fz5' size='340' side='right' caption='[[4fz5]], [[Resolution|resolution]] 3.60Å' scene=''> | + | <StructureSection load='4fz5' size='340' side='right'caption='[[4fz5]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4fz5]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4fz5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZ5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [https://pdbe.org/4fz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4fz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fz5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> |
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| + | ==See Also== | ||
| + | *[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Kim S]] |
| - | [[Category: | + | [[Category: Park S]] |
| - | [[Category: | + | [[Category: Shoelson SE]] |
| - | [[Category: | + | [[Category: Woo JR]] |
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Current revision
Crystal Structure of Human TIRAP TIR-domain
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Categories: Homo sapiens | Large Structures | Kim S | Park S | Shoelson SE | Woo JR
