4pw8

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==Human tryptophan 2,3-dioxygenase==
==Human tryptophan 2,3-dioxygenase==
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<StructureSection load='4pw8' size='340' side='right' caption='[[4pw8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4pw8' size='340' side='right'caption='[[4pw8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pw8]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pw8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PW8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.902&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pw8 RCSB], [http://www.ebi.ac.uk/pdbsum/4pw8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pw8 OCA], [https://pdbe.org/4pw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pw8 RCSB], [https://www.ebi.ac.uk/pdbsum/4pw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pw8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
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[https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tryptophan 2,3-dioxygenase (TDO), one of the two key enzymes in the kynurenine pathway, catalyzes the indole ring cleavage at the C2-C3 bond of L-tryptophan. This is a rate-limiting step in the regulation of tryptophan concentration in vivo, and is thus important in drug discovery for cancer and immune diseases. Here, we report the crystal structure of human TDO (hTDO) without the heme cofactor to 2.90 A resolution. The overall fold and the tertiary assembly of hTDO into a tetramer, as well as the active site architecture, are well conserved and similar to the structures of known orthologues. Kinetic and mutational studies confirmed that eight residues play critical roles in L-tryptophan oxidation.
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Structural and functional analyses of human tryptophan 2,3-dioxygenase.,Meng B, Wu D, Gu J, Ouyang S, Ding W, Liu ZJ Proteins. 2014 Nov;82(11):3210-6. doi: 10.1002/prot.24653. Epub 2014 Aug 30. PMID:25066423<ref>PMID:25066423</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4pw8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Tryptophan 2,3-dioxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Ding, W]]
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[[Category: Large Structures]]
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[[Category: Gu, J H]]
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[[Category: Ding W]]
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[[Category: Liu, Z J]]
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[[Category: Gu JH]]
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[[Category: Meng, B]]
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[[Category: Liu ZJ]]
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[[Category: Ouyang, S Y]]
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[[Category: Meng B]]
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[[Category: Wu, D]]
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[[Category: Ouyang SY]]
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[[Category: Dioxygenase]]
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[[Category: Wu D]]
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[[Category: Oxidoreductase]]
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Current revision

Human tryptophan 2,3-dioxygenase

PDB ID 4pw8

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