4bwk
From Proteopedia
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==Structure of Neurospora crassa PAN3 pseudokinase== | ==Structure of Neurospora crassa PAN3 pseudokinase== | ||
| - | <StructureSection load='4bwk' size='340' side='right' caption='[[4bwk]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='4bwk' size='340' side='right'caption='[[4bwk]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bwk]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4bwk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWK FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwk OCA], [https://pdbe.org/4bwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwk RCSB], [https://www.ebi.ac.uk/pdbsum/4bwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwk ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PAN3_NEUCR PAN3_NEUCR] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4bwk" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Neurospora crassa]] | [[Category: Neurospora crassa]] | ||
| - | [[Category: Boland | + | [[Category: Boland A]] |
| - | [[Category: Christie | + | [[Category: Christie M]] |
| - | [[Category: Huntzinger | + | [[Category: Huntzinger E]] |
| - | [[Category: Izaurralde | + | [[Category: Izaurralde E]] |
| - | [[Category: Weichenrieder | + | [[Category: Weichenrieder O]] |
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Current revision
Structure of Neurospora crassa PAN3 pseudokinase
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