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2exb

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==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, complexed with FLOMOX==
==Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, complexed with FLOMOX==
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<StructureSection load='2exb' size='340' side='right' caption='[[2exb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='2exb' size='340' side='right'caption='[[2exb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2exb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2exb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FXM:2,2-DIMETHYLPROPANOYLOXYMETHYL+(6R,7R)-7-[(Z)-2-(2-AMINOTHIAZOL-4-YL)PENT-2-ENYLAMINO]-3-CARBAMOYLOXYMETHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE'>FXM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ex2|2ex2]], [[2ex6|2ex6]], [[2ex8|2ex8]], [[2ex9|2ex9]], [[2exa|2exa]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FXM:2,2-DIMETHYLPROPANOYLOXYMETHYL+(2R)-5-(AMINOCARBONYLOXYMETHYL)-2-[(1R)-1-[[(Z)-2-(2-AZANYL-1,3-THIAZOL-4-YL)PENT-2-ENOYL]AMINO]-2-OXIDANYLIDENE-ETHYL]-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLATE'>FXM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dacb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exb OCA], [https://pdbe.org/2exb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exb RCSB], [https://www.ebi.ac.uk/pdbsum/2exb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2exb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2exb RCSB], [http://www.ebi.ac.uk/pdbsum/2exb PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PBP4_ECOLI PBP4_ECOLI]] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>
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[https://www.uniprot.org/uniprot/DACB_ECOLI DACB_ECOLI] Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.<ref>PMID:2046551</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exb_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exb ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2exb" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Penicillin-binding protein|Penicillin-binding protein]]
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Kishida, H]]
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[[Category: Large Structures]]
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[[Category: Lloyd, A]]
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[[Category: Kishida H]]
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[[Category: Park, S Y]]
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[[Category: Lloyd A]]
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[[Category: Roper, D I]]
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[[Category: Park S-Y]]
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[[Category: Tame, J R.H]]
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[[Category: Roper DI]]
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[[Category: Unzai, S]]
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[[Category: Tame JRH]]
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[[Category: Cephem]]
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[[Category: Unzai S]]
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[[Category: D-alanyl-d-alanine-carboxypeptidase]]
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[[Category: D-alanyl-d-alanine-endopeptidase]]
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[[Category: Flomox]]
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[[Category: Hydrolase]]
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[[Category: Penem]]
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[[Category: Penicillin]]
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[[Category: Penicillin-binding protein]]
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Current revision

Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, complexed with FLOMOX

PDB ID 2exb

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