This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4h84

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:01, 20 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.==
==Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.==
-
<StructureSection load='4h84' size='340' side='right' caption='[[4h84]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+
<StructureSection load='4h84' size='340' side='right'caption='[[4h84]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4h84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H84 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4h84]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H84 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene>, <scene name='pdbligand=Y38:N-[2-(BENZOYLAMINO)ETHYL]-N-(BIPHENYL-4-YLSULFONYL)-D-VALINE'>Y38</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.592&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h30|4h30]], [[4h49|4h49]], [[4h76|4h76]], [[3ts4|3ts4]], [[3tsk|3tsk]], [[4efs|4efs]], [[4h82|4h82]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene>, <scene name='pdbligand=Y38:N-[2-(BENZOYLAMINO)ETHYL]-N-(BIPHENYL-4-YLSULFONYL)-D-VALINE'>Y38</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME, MMP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h84 OCA], [https://pdbe.org/4h84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h84 RCSB], [https://www.ebi.ac.uk/pdbsum/4h84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h84 ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h84 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h84 RCSB], [http://www.ebi.ac.uk/pdbsum/4h84 PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
+
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4h84" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
+
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Macrophage elastase]]
+
[[Category: Large Structures]]
-
[[Category: Antoni, C]]
+
[[Category: Antoni C]]
-
[[Category: Cassar-Lajeunesse, E]]
+
[[Category: Cassar-Lajeunesse E]]
-
[[Category: Dive, V]]
+
[[Category: Dive V]]
-
[[Category: Nuti, E]]
+
[[Category: Nuti E]]
-
[[Category: Rossello, A]]
+
[[Category: Rossello A]]
-
[[Category: Stura, E A]]
+
[[Category: Stura EA]]
-
[[Category: Vera, L]]
+
[[Category: Vera L]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Metzincin]]
+
-
[[Category: Selective carboxylate based mmp-12 inhibitor]]
+
-
[[Category: Zinc protease]]
+

Current revision

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

PDB ID 4h84

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4h84"
Personal tools