4ja3

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==Partially occluded inward open conformation of the xylose transporter XylE from E. coli==
==Partially occluded inward open conformation of the xylose transporter XylE from E. coli==
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<StructureSection load='4ja3' size='340' side='right' caption='[[4ja3]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<StructureSection load='4ja3' size='340' side='right'caption='[[4ja3]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ja3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ja3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ja4|4ja4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">xylE, b4031, JW3991 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja3 OCA], [https://pdbe.org/4ja3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ja3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja3 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/XYLE_ECOLI XYLE_ECOLI]] Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
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[https://www.uniprot.org/uniprot/XYLE_ECOLI XYLE_ECOLI] Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.
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Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.,Quistgaard EM, Low C, Moberg P, Tresaugues L, Nordlund P Nat Struct Mol Biol. 2013 Jun;20(6):766-8. doi: 10.1038/nsmb.2569. Epub 2013 Apr , 28. PMID:23624861<ref>PMID:23624861</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Symporter 3D structures|Symporter 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli k-12]]
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[[Category: Escherichia coli K-12]]
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[[Category: Low, C]]
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[[Category: Large Structures]]
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[[Category: Moberg, P]]
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[[Category: Low C]]
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[[Category: Nordlund, P]]
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[[Category: Moberg P]]
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[[Category: Quistgaard, E M]]
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[[Category: Nordlund P]]
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[[Category: Tresaugues, L]]
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[[Category: Quistgaard EM]]
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[[Category: Mfs general substrate transporter]]
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[[Category: Tresaugues L]]
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[[Category: Transport protein]]
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[[Category: Xylose transporter]]
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Current revision

Partially occluded inward open conformation of the xylose transporter XylE from E. coli

PDB ID 4ja3

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