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4gyq

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Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae

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 ==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae==
-<StructureSection load='4gyq' size='340' side='right' caption='[[4gyq]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
+<StructureSection load='4gyq' size='340' side='right'caption='[[4gyq]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GYQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4gyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GYQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.351&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyq OCA], [https://pdbe.org/4gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gyq RCSB], [https://www.ebi.ac.uk/pdbsum/4gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gyq ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gyq RCSB], [http://www.ebi.ac.uk/pdbsum/4gyq PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
+[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
 ==See Also==
-*[[Beta-lactamase|Beta-lactamase]]
+*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Beta-lactamase]]
 [[Category: Klebsiella pneumoniae]]
-[[Category: Babnigg, J]]
+[[Category: Large Structures]]
-[[Category: Binkowski, T A]]
+[[Category: Babnigg J]]
-[[Category: Jedrzejczak, R]]
+[[Category: Binkowski TA]]
-[[Category: Joachimiak, A]]
+[[Category: Jedrzejczak R]]
-[[Category: Kim, Y]]
+[[Category: Joachimiak A]]
-[[Category: Structural genomic]]
+[[Category: Kim Y]]
-[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
+[[Category: MCSG]]
-[[Category: Mcsg]]
+[[Category: Mire J]]
-[[Category: Mire, J]]
+[[Category: Sacchettini J]]
-[[Category: Sacchettini, J]]
+[[Category: Tesar C]]
-[[Category: Tesar, C]]
-[[Category: Alpha-beta-beta-alpha fold]]
-[[Category: Hydrolase]]
-[[Category: Mtbi]]
-[[Category: Psi-biology]]
-[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]

4gyq

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Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae

Structural highlights

Function

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