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4a7e

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==X-ray crystal structure of porcine insulin flash-cooled at high pressure==
==X-ray crystal structure of porcine insulin flash-cooled at high pressure==
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<StructureSection load='4a7e' size='340' side='right' caption='[[4a7e]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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<StructureSection load='4a7e' size='340' side='right'caption='[[4a7e]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a7e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a7e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A7E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zei|1zei]], [[1b2g|1b2g]], [[3ins|3ins]], [[1wav|1wav]], [[1b2b|1b2b]], [[1b2f|1b2f]], [[1m5a|1m5a]], [[9ins|9ins]], [[1b2d|1b2d]], [[1dei|1dei]], [[1b17|1b17]], [[1sdb|1sdb]], [[1b2a|1b2a]], [[1izb|1izb]], [[2tci|2tci]], [[1b2c|1b2c]], [[4ins|4ins]], [[7ins|7ins]], [[1iza|1iza]], [[3mth|3mth]], [[1b19|1b19]], [[1mpj|1mpj]], [[1zni|1zni]], [[1b2e|1b2e]], [[1b18|1b18]], [[4a7d|4a7d]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.856&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7e RCSB], [http://www.ebi.ac.uk/pdbsum/4a7e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7e OCA], [https://pdbe.org/4a7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a7e RCSB], [https://www.ebi.ac.uk/pdbsum/4a7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
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[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4a7e" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Molecular Playground/Insulin|Molecular Playground/Insulin]]
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*[[Insulin 3D Structures|Insulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Burkhardt, A]]
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[[Category: Burkhardt A]]
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[[Category: Hohenberg, H]]
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[[Category: Hohenberg H]]
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[[Category: Meents, A]]
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[[Category: Meents A]]
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[[Category: Panneerselvam, S]]
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[[Category: Panneerselvam S]]
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[[Category: Reimer, R]]
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[[Category: Reimer R]]
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[[Category: Wagner, A]]
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[[Category: Wagner A]]
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[[Category: Warmer, M]]
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[[Category: Warmer M]]
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[[Category: High-pressure cooling]]
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[[Category: High-pressure protein crystallography]]
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[[Category: Hormone]]
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Current revision

X-ray crystal structure of porcine insulin flash-cooled at high pressure

PDB ID 4a7e

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