3mea

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:52, 6 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
 +
==Crystal structure of the SGF29 in complex with H3K4me3==
==Crystal structure of the SGF29 in complex with H3K4me3==
-
<StructureSection load='3mea' size='340' side='right' caption='[[3mea]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
+
<StructureSection load='3mea' size='340' side='right'caption='[[3mea]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3mea]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MEA FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3mea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MEA FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.26&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3me9|3me9]], [[3met|3met]], [[3meu|3meu]], [[3mev|3mev]], [[3mew|3mew]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCDC101, SGF29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mea OCA], [https://pdbe.org/3mea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mea RCSB], [https://www.ebi.ac.uk/pdbsum/3mea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mea ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mea RCSB], [http://www.ebi.ac.uk/pdbsum/3mea PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN]] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref>
+
[https://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3mea_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3mea_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mea ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 28: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3mea" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
Line 36: Line 37:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Large Structures]]
-
[[Category: Bian, C]]
+
[[Category: Xenopus laevis]]
-
[[Category: Bochkarev, A]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bian C]]
-
[[Category: Edwards, A M]]
+
[[Category: Bochkarev A]]
-
[[Category: MacKenzie, F]]
+
[[Category: Bountra C]]
-
[[Category: Min, J]]
+
[[Category: Edwards AM]]
-
[[Category: Structural genomic]]
+
[[Category: MacKenzie F]]
-
[[Category: Tempel, W]]
+
[[Category: Min J]]
-
[[Category: Weigelt, J]]
+
[[Category: Tempel W]]
-
[[Category: Xu, C]]
+
[[Category: Weigelt J]]
-
[[Category: Chromosomal protein]]
+
[[Category: Xu C]]
-
[[Category: Dna-binding]]
+
-
[[Category: Nucleosome core]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+

Current revision

Crystal structure of the SGF29 in complex with H3K4me3

PDB ID 3mea

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mea"
Personal tools