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3rfm

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==Thermostabilised adenosine A2A receptor in complex with caffeine==
==Thermostabilised adenosine A2A receptor in complex with caffeine==
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<StructureSection load='3rfm' size='340' side='right' caption='[[3rfm]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='3rfm' size='340' side='right'caption='[[3rfm]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rfm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RFM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RFM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CFF:CAFFEINE'>CFF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.598&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pwh|3pwh]], [[3rey|3rey]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CFF:CAFFEINE'>CFF</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rfm OCA], [https://pdbe.org/3rfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rfm RCSB], [https://www.ebi.ac.uk/pdbsum/3rfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rfm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rfm RCSB], [http://www.ebi.ac.uk/pdbsum/3rfm PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3rfm" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Adenosine A2A receptor|Adenosine A2A receptor]]
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bennett, K]]
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[[Category: Large Structures]]
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[[Category: Congreve, M]]
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[[Category: Bennett K]]
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[[Category: Dore, A S]]
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[[Category: Congreve M]]
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[[Category: Errey, J C]]
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[[Category: Dore AS]]
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[[Category: Hollenstein, K]]
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[[Category: Errey JC]]
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[[Category: Hurrell, E]]
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[[Category: Hollenstein K]]
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[[Category: Magnani, F]]
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[[Category: Hurrell E]]
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[[Category: Marshall, F H]]
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[[Category: Magnani F]]
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[[Category: Ng, I]]
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[[Category: Marshall FH]]
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[[Category: Robertson, N]]
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[[Category: Ng I]]
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[[Category: Tate, C G]]
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[[Category: Robertson N]]
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[[Category: Tehan, B]]
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[[Category: Tate CG]]
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[[Category: Weir, M]]
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[[Category: Tehan B]]
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[[Category: G-protein]]
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[[Category: Weir M]]
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[[Category: Gpcr]]
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[[Category: Inverse agonist]]
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[[Category: Membrane protein]]
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[[Category: Signaling protein]]
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Current revision

Thermostabilised adenosine A2A receptor in complex with caffeine

PDB ID 3rfm

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