This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2f0z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:44, 25 October 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f0z.jpg|left|200px]]
 
-
{{Structure
+
==Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor==
-
|PDB= 2f0z |SIZE=350|CAPTION= <scene name='initialview01'>2f0z</scene>, resolution 2.800&Aring;
+
<StructureSection load='2f0z' size='340' side='right'caption='[[2f0z]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>
+
<table><tr><td colspan='2'>[[2f0z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F0Z FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f0z OCA], [https://pdbe.org/2f0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f0z RCSB], [https://www.ebi.ac.uk/pdbsum/2f0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f0z ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f0z_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f0z ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor'''
+
==See Also==
-
 
+
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2F0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F0Z OCA].
+
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Chavas, L M.G.]]
+
[[Category: Chavas LMG]]
-
[[Category: Colman, P M.]]
+
[[Category: Colman PM]]
-
[[Category: Fusi, P.]]
+
[[Category: Fusi P]]
-
[[Category: Kato, R.]]
+
[[Category: Kato R]]
-
[[Category: McKimm-Breschkin, J.]]
+
[[Category: McKimm-Breschkin J]]
-
[[Category: Monti, E.]]
+
[[Category: Monti E]]
-
[[Category: Tettamanti, G.]]
+
[[Category: Tettamanti G]]
-
[[Category: Tringali, C.]]
+
[[Category: Tringali C]]
-
[[Category: Venerando, B.]]
+
[[Category: Venerando B]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Wakatsuki S]]
-
[[Category: ZMR]]
+
-
[[Category: influenza virus]]
+
-
[[Category: neuraminidase]]
+
-
[[Category: sialidase]]
+
-
[[Category: zanamivir]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:46:49 2008''
+

Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor

PDB ID 2f0z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f0z"
Personal tools