2f27

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[[Image:2f27.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor==
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|PDB= 2f27 |SIZE=350|CAPTION= <scene name='initialview01'>2f27</scene>, resolution 2.150&Aring;
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<StructureSection load='2f27' size='340' side='right'caption='[[2f27]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
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<table><tr><td colspan='2'>[[2f27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F27 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f27 OCA], [https://pdbe.org/2f27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f27 RCSB], [https://www.ebi.ac.uk/pdbsum/2f27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f27 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f27_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f27 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor'''
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==See Also==
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2F27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F27 OCA].
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[[Category: Exo-alpha-sialidase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chavas, L M.G.]]
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[[Category: Chavas LMG]]
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[[Category: Fusi, P.]]
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[[Category: Fusi P]]
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[[Category: Kato, R.]]
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[[Category: Kato R]]
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[[Category: Monti, E.]]
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[[Category: Monti E]]
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[[Category: Tettamanti, G.]]
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[[Category: Tettamanti G]]
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[[Category: Tringali, C.]]
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[[Category: Tringali C]]
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[[Category: Venerando, B.]]
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[[Category: Venerando B]]
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[[Category: Wakatsuki, S.]]
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[[Category: Wakatsuki S]]
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[[Category: DAN]]
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[[Category: EPE]]
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[[Category: drug design]]
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[[Category: ganglioside]]
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[[Category: neuraminidase]]
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[[Category: sialidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:10 2008''
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Current revision

Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor

PDB ID 2f27

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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