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4cc3

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==Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3==
==Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3==
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<StructureSection load='4cc3' size='340' side='right' caption='[[4cc3]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='4cc3' size='340' side='right'caption='[[4cc3]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cc3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cc3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cc2|4cc2]], [[4cc4|4cc4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cc3 RCSB], [http://www.ebi.ac.uk/pdbsum/4cc3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cc3 OCA], [https://pdbe.org/4cc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cc3 RCSB], [https://www.ebi.ac.uk/pdbsum/4cc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cc3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNMBP_HUMAN DNMBP_HUMAN]] Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). [[http://www.uniprot.org/uniprot/ENAH_MOUSE ENAH_MOUSE]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.<ref>PMID:8861907</ref> <ref>PMID:10069337</ref> <ref>PMID:12134088</ref> <ref>PMID:15066263</ref>
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[https://www.uniprot.org/uniprot/DNMBP_HUMAN DNMBP_HUMAN] Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cc3" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ireton, K]]
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[[Category: Large Structures]]
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[[Category: Julian, R]]
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[[Category: Mus musculus]]
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[[Category: Polle, L]]
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[[Category: Ireton K]]
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[[Category: Rigano, L]]
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[[Category: Julian R]]
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[[Category: Schubert, W D]]
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[[Category: Polle L]]
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[[Category: Actin cytoskeleton]]
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[[Category: Rigano L]]
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[[Category: Cortical tension]]
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[[Category: Schubert W-D]]
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[[Category: Mena]]
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[[Category: Ndpp-1]]
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[[Category: Proline- rich peptide]]
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[[Category: Sh3 domain]]
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[[Category: Src homology 3]]
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[[Category: Structural protein]]
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[[Category: Tuba]]
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Current revision

Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3

PDB ID 4cc3

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