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3zef

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==Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 A resolution==
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<StructureSection load='3zef' size='340' side='right' caption='[[3zef]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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==Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution==
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<StructureSection load='3zef' size='340' side='right'caption='[[3zef]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zef]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZEF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZEF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i43|4i43]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zef RCSB], [http://www.ebi.ac.uk/pdbsum/3zef PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zef OCA], [https://pdbe.org/3zef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zef RCSB], [https://www.ebi.ac.uk/pdbsum/3zef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AAR2_YEAST AAR2_YEAST]] Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth. [[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
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[https://www.uniprot.org/uniprot/AAR2_YEAST AAR2_YEAST] Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3zef" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Galej, W P]]
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[[Category: Galej WP]]
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[[Category: Nagai, K]]
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[[Category: Nagai K]]
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[[Category: Newman, A J]]
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[[Category: Newman AJ]]
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[[Category: Oubridge, C]]
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[[Category: Oubridge C]]
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[[Category: Pre-mrna splicing]]
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[[Category: Spliceosome]]
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[[Category: Translation]]
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[[Category: U5 snrnp]]
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Current revision

Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution

PDB ID 3zef

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