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4gi4

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==tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor==
==tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor==
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<StructureSection load='4gi4' size='340' side='right' caption='[[4gi4]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='4gi4' size='340' side='right'caption='[[4gi4]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gi4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GI4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GI4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0EX:6-AMINO-4-[2-(BENZYLAMINO)ETHYL]-2-[(2-PHENYLETHYL)AMINO]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0EX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gh3|4gh3]], [[4gh1|4gh1]], [[4gg9|4gg9]], [[3gc4|3gc4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0EX:6-AMINO-4-[2-(BENZYLAMINO)ETHYL]-2-[(2-PHENYLETHYL)AMINO]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0EX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gi4 OCA], [https://pdbe.org/4gi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gi4 RCSB], [https://www.ebi.ac.uk/pdbsum/4gi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gi4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gi4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gi4 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
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[https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
==See Also==
==See Also==
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*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]]
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*[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]
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[[Category: Large Structures]]
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[[Category: Immekus, F]]
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[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
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[[Category: Klebe, G]]
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[[Category: Immekus F]]
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[[Category: Biosynthesis]]
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[[Category: Klebe G]]
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[[Category: Queuosine]]
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[[Category: Tim barrel glycosyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trna]]
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[[Category: Trna processing]]
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Current revision

tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor

PDB ID 4gi4

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