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4a6d

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==Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM==
==Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM==
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<StructureSection load='4a6d' size='340' side='right' caption='[[4a6d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4a6d' size='340' side='right'caption='[[4a6d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A6D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a6e|4a6e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylserotonin_O-methyltransferase Acetylserotonin O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.4 2.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6d OCA], [https://pdbe.org/4a6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6d RCSB], [https://www.ebi.ac.uk/pdbsum/4a6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a6d RCSB], [http://www.ebi.ac.uk/pdbsum/4a6d PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASMT_HUMAN ASMT_HUMAN]] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.<ref>PMID:22775292</ref>
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[https://www.uniprot.org/uniprot/ASMT_HUMAN ASMT_HUMAN] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.<ref>PMID:22775292</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4a6d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylserotonin O-methyltransferase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Haouz, A]]
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[[Category: Large Structures]]
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[[Category: Legrand, P]]
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[[Category: Haouz A]]
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[[Category: Shepard, W]]
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[[Category: Legrand P]]
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[[Category: Circadian clock]]
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[[Category: Shepard W]]
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[[Category: Melatonin]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM

PDB ID 4a6d

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