4cga

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==Human choline kinase a1 in complex with compound 5==
==Human choline kinase a1 in complex with compound 5==
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<StructureSection load='4cga' size='340' side='right' caption='[[4cga]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='4cga' size='340' side='right'caption='[[4cga]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cga]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLW:N,N-DIMETHYL-1-[[4-(2-PHENYLETHYL)PHENYL]METHYL]PYRIDIN-1-IUM-4-AMINE'>QLW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cg8|4cg8]], [[4cg9|4cg9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QLW:N,N-DIMETHYL-1-[[4-(2-PHENYLETHYL)PHENYL]METHYL]PYRIDIN-1-IUM-4-AMINE'>QLW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cga RCSB], [http://www.ebi.ac.uk/pdbsum/4cga PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cga OCA], [https://pdbe.org/4cga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cga RCSB], [https://www.ebi.ac.uk/pdbsum/4cga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cga ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cga" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Choline kinase|Choline kinase]]
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Capitan-Canadas, F]]
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[[Category: Large Structures]]
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[[Category: Carrasco, M P]]
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[[Category: Capitan-Canadas F]]
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[[Category: Concepcion, C]]
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[[Category: Carrasco MP]]
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[[Category: Conejo-Garcia, A]]
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[[Category: Concepcion C]]
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[[Category: Entrena-Guadix, A]]
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[[Category: Conejo-Garcia A]]
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[[Category: Espinosa, A]]
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[[Category: Entrena-Guadix A]]
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[[Category: Figuerola-Conchas, A]]
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[[Category: Espinosa A]]
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[[Category: Gallo, M A]]
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[[Category: Figuerola-Conchas A]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Gallo MA]]
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[[Category: Marco, C]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Ramos-Torrecillas, J]]
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[[Category: Marco C]]
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[[Category: Rios-Marco, P]]
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[[Category: Ramos-Torrecillas J]]
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[[Category: Rubio-Ruiz, B]]
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[[Category: Rios-Marco P]]
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[[Category: Biscationic compound]]
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[[Category: Rubio-Ruiz B]]
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[[Category: Cancer]]
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[[Category: Drug target]]
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[[Category: Transferase]]
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Current revision

Human choline kinase a1 in complex with compound 5

PDB ID 4cga

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