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4na2

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==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate==
==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate==
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<StructureSection load='4na2' size='340' side='right' caption='[[4na2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4na2' size='340' side='right'caption='[[4na2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4na2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NA2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4na2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NA2 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JF:(2S)-2-AMINO-3-OXOPROPYL+4-{[(2S)-2-HYDROXY-4-METHYLPENTANOYL]AMINO}BUTANOATE'>2JF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qo3|2qo3]], [[2hg4|2hg4]], [[4na1|4na1]], [[4na3|4na3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2JF:(2S)-2-AMINO-3-OXOPROPYL+4-{[(2S)-2-HYDROXY-4-METHYLPENTANOYL]AMINO}BUTANOATE'>2JF</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pksJ, pksK, BSU17180 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4na2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na2 OCA], [https://pdbe.org/4na2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4na2 RCSB], [https://www.ebi.ac.uk/pdbsum/4na2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4na2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4na2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4na2 RCSB], [http://www.ebi.ac.uk/pdbsum/4na2 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>
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[https://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4na2" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacsu]]
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Gay, D C]]
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[[Category: Large Structures]]
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[[Category: Gay, G R]]
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[[Category: Gay DC]]
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[[Category: Keatinge-Clay, A T]]
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[[Category: Gay GR]]
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[[Category: Condensing enzyme fold]]
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[[Category: Keatinge-Clay AT]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate

PDB ID 4na2

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