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2w73

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==HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A==
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<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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==High-resolution structure of the complex between calmodulin and a peptide from calcineurin A==
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<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j7p|1j7p]], [[2f3z|2f3z]], [[1mf8|1mf8]], [[1nkf|1nkf]], [[2jl2|2jl2]], [[1xfv|1xfv]], [[1k93|1k93]], [[1sk6|1sk6]], [[1y6w|1y6w]], [[1iwq|1iwq]], [[1k90|1k90]], [[1yrt|1yrt]], [[1lvc|1lvc]], [[1cll|1cll]], [[1cdl|1cdl]], [[1xfu|1xfu]], [[1xfy|1xfy]], [[2f3y|2f3y]], [[1xfx|1xfx]], [[1s26|1s26]], [[1j7o|1j7o]], [[1aui|1aui]], [[1yru|1yru]], [[1wrz|1wrz]], [[2v02|2v02]], [[1xfz|1xfz]], [[1xfw|1xfw]], [[2v01|2v01]], [[1pk0|1pk0]], [[1m63|1m63]], [[2be6|2be6]], [[1zot|1zot]], [[1sw8|1sw8]], [[2vay|2vay]], [[1aji|1aji]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [https://pdbe.org/2w73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [https://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
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[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w73_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w73_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w73 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Calcineurin|Calcineurin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Calmodulin|Calmodulin]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Kursula, P]]
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[[Category: Kursula P]]
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[[Category: Majava, V]]
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[[Category: Majava V]]
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[[Category: Calmodulin]]
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[[Category: Calmodulin-binding]]
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[[Category: Dimer]]
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[[Category: Ef hand]]
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[[Category: Hydrolase]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Metal-binding protein]]
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[[Category: Methylation]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein phosphatase]]
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Current revision

High-resolution structure of the complex between calmodulin and a peptide from calcineurin A

PDB ID 2w73

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