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4bkx

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==The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex==
==The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex==
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<StructureSection load='4bkx' size='340' side='right' caption='[[4bkx]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4bkx' size='340' side='right'caption='[[4bkx]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkx RCSB], [http://www.ebi.ac.uk/pdbsum/4bkx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkx OCA], [https://pdbe.org/4bkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkx RCSB], [https://www.ebi.ac.uk/pdbsum/4bkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTA1_HUMAN MTA1_HUMAN]] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
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[https://www.uniprot.org/uniprot/MTA1_HUMAN MTA1_HUMAN] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bkx" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Histone deacetylase|Histone deacetylase]]
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histone deacetylase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Celardo, I]]
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[[Category: Large Structures]]
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[[Category: Cowley, S M]]
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[[Category: Celardo I]]
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[[Category: Fairall, L]]
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[[Category: Cowley SM]]
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[[Category: Gordiyenko, Y]]
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[[Category: Fairall L]]
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[[Category: Millard, C J]]
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[[Category: Gordiyenko Y]]
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[[Category: Robinson, C V]]
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[[Category: Millard CJ]]
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[[Category: Schwabe, J W.R]]
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[[Category: Robinson CV]]
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[[Category: Watson, P J]]
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[[Category: Schwabe JWR]]
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[[Category: Elm2-sant domain]]
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[[Category: Watson PJ]]
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[[Category: Hdac]]
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[[Category: Hdac1]]
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[[Category: Inositol phosphate signalling]]
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[[Category: Mta1]]
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[[Category: Transcription]]
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Current revision

The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex

PDB ID 4bkx

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