This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3v6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:16, 8 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
-
<StructureSection load='3v6a' size='340' side='right' caption='[[3v6a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='3v6a' size='340' side='right'caption='[[3v6a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3v6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6A FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3v6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6A FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u0r|3u0r]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">API5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [https://pdbe.org/3v6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [https://www.ebi.ac.uk/pdbsum/3v6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6a ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [http://www.ebi.ac.uk/pdbsum/3v6a PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
+
[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3v6a" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 22: Line 23:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Han, B G]]
+
[[Category: Large Structures]]
-
[[Category: Lee, B I]]
+
[[Category: Han BG]]
-
[[Category: Lee, S J]]
+
[[Category: Lee BI]]
-
[[Category: Acinus]]
+
[[Category: Lee SJ]]
-
[[Category: Apoptosis inhibitor]]
+
-
[[Category: Fgf-2]]
+
-
[[Category: Heat and armadillo-like repeat]]
+
-
[[Category: Nucleus]]
+

Current revision

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

PDB ID 3v6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v6a"
Personal tools