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4gdy
From Proteopedia
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==Kynurenine Aminotransferase II inhibitors== | ==Kynurenine Aminotransferase II inhibitors== | ||
| - | <StructureSection load='4gdy' size='340' side='right' caption='[[4gdy]], [[Resolution|resolution]] 2.89Å' scene=''> | + | <StructureSection load='4gdy' size='340' side='right'caption='[[4gdy]], [[Resolution|resolution]] 2.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4gdy]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4gdy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GDY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0X1:(5-HYDROXY-6-METHYL-4-{[(1-OXO-7-PHENOXY-1,2-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0X1</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0X1:(5-HYDROXY-6-METHYL-4-{[(1-OXO-7-PHENOXY-1,2-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0X1</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gdy OCA], [https://pdbe.org/4gdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gdy RCSB], [https://www.ebi.ac.uk/pdbsum/4gdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gdy ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Pandit J]] |
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Current revision
Kynurenine Aminotransferase II inhibitors
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