3cfs
From Proteopedia
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==Structural basis of the interaction of RbAp46/RbAp48 with histone H4== | ==Structural basis of the interaction of RbAp46/RbAp48 with histone H4== | ||
| - | <StructureSection load='3cfs' size='340' side='right' caption='[[3cfs]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='3cfs' size='340' side='right'caption='[[3cfs]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3cfs]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3cfs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfs OCA], [https://pdbe.org/3cfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfs RCSB], [https://www.ebi.ac.uk/pdbsum/3cfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfs ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RBBP7_HUMAN RBBP7_HUMAN] Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfs_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfs ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3cfs" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]] | *[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]] | ||
| + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ben-Shahar | + | [[Category: Large Structures]] |
| - | [[Category: Laue | + | [[Category: Ben-Shahar TR]] |
| - | [[Category: Luisi | + | [[Category: Laue ED]] |
| - | [[Category: Murzina | + | [[Category: Luisi BF]] |
| - | [[Category: Pei | + | [[Category: Murzina NV]] |
| - | [[Category: Pratap | + | [[Category: Pei X-Y]] |
| - | [[Category: Sparkes | + | [[Category: Pratap JV]] |
| - | [[Category: Verreault | + | [[Category: Sparkes M]] |
| - | [[Category: Vicente-Garcia | + | [[Category: Verreault A]] |
| - | + | [[Category: Vicente-Garcia J]] | |
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Current revision
Structural basis of the interaction of RbAp46/RbAp48 with histone H4
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Categories: Homo sapiens | Large Structures | Ben-Shahar TR | Laue ED | Luisi BF | Murzina NV | Pei X-Y | Pratap JV | Sparkes M | Verreault A | Vicente-Garcia J
