1zt5
From Proteopedia
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==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)== | ==C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)== | ||
| - | <StructureSection load='1zt5' size='340' side='right' caption='[[1zt5]], [[Resolution|resolution]] 1.82Å' scene=''> | + | <StructureSection load='1zt5' size='340' side='right'caption='[[1zt5]], [[Resolution|resolution]] 1.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1zt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.818Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt5 OCA], [https://pdbe.org/1zt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zt5_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zt5_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zt5 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1zt5" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Campagnoli | + | [[Category: Large Structures]] |
| - | [[Category: Capaldi | + | [[Category: Campagnoli M]] |
| - | [[Category: Carrizo | + | [[Category: Capaldi S]] |
| - | [[Category: Faggion | + | [[Category: Carrizo ME]] |
| - | [[Category: Galliano | + | [[Category: Faggion B]] |
| - | [[Category: Labo | + | [[Category: Galliano M]] |
| - | [[Category: Minchiotti | + | [[Category: Labo S]] |
| - | [[Category: Monaco | + | [[Category: Minchiotti L]] |
| - | [[Category: Perduca | + | [[Category: Monaco HL]] |
| - | [[Category: Romano | + | [[Category: Perduca M]] |
| - | [[Category: Sala | + | [[Category: Romano A]] |
| - | [[Category: Valli | + | [[Category: Sala A]] |
| - | [[Category: Visai | + | [[Category: Valli M]] |
| - | + | [[Category: Visai L]] | |
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Current revision
C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)
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Categories: Homo sapiens | Large Structures | Campagnoli M | Capaldi S | Carrizo ME | Faggion B | Galliano M | Labo S | Minchiotti L | Monaco HL | Perduca M | Romano A | Sala A | Valli M | Visai L
