3tkr

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==Crystal structure of full-length human peroxiredoxin 4 with T118E mutation==
==Crystal structure of full-length human peroxiredoxin 4 with T118E mutation==
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<StructureSection load='3tkr' size='340' side='right' caption='[[3tkr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3tkr' size='340' side='right'caption='[[3tkr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tkr]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TKR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tkr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pn8|2pn8]], [[3tkp|3tkp]], [[3tkq|3tkq]], [[3tks|3tks]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkr OCA], [https://pdbe.org/3tkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkr RCSB], [https://www.ebi.ac.uk/pdbsum/3tkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tkr RCSB], [http://www.ebi.ac.uk/pdbsum/3tkr PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN]] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
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[https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3tkr" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peroxiredoxin]]
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[[Category: Large Structures]]
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[[Category: Sun, F]]
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[[Category: Sun F]]
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[[Category: Wang, C C]]
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[[Category: Wang C-C]]
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[[Category: Wang, L]]
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[[Category: Wang L]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Oxidoreductase]]
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[[Category: Trx fold]]
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Current revision

Crystal structure of full-length human peroxiredoxin 4 with T118E mutation

PDB ID 3tkr

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