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2oaz
From Proteopedia
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==Human Methionine Aminopeptidase-2 Complexed with SB-587094== | ==Human Methionine Aminopeptidase-2 Complexed with SB-587094== | ||
| - | <StructureSection load='2oaz' size='340' side='right' caption='[[2oaz]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2oaz' size='340' side='right'caption='[[2oaz]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2oaz]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2oaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=I96:N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE'>I96</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=I96:N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE'>I96</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oaz OCA], [https://pdbe.org/2oaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oaz RCSB], [https://www.ebi.ac.uk/pdbsum/2oaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oaz ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MAP2_HUMAN MAP2_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oaz_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oaz_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oaz ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2oaz" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Aminopeptidase|Aminopeptidase]] | + | *[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Fisher | + | [[Category: Fisher PW]] |
| - | [[Category: Hofmann | + | [[Category: Hofmann GA]] |
| - | [[Category: Janson | + | [[Category: Janson CA]] |
| - | [[Category: Johnson | + | [[Category: Johnson RK]] |
| - | [[Category: Kirkpatrick | + | [[Category: Kirkpatrick R]] |
| - | [[Category: Ma | + | [[Category: Ma C]] |
| - | [[Category: Marino | + | [[Category: Marino Jr JP]] |
| - | [[Category: Mattern | + | [[Category: Mattern M]] |
| - | [[Category: Meek | + | [[Category: Meek TD]] |
| - | [[Category: Ryan | + | [[Category: Ryan D]] |
| - | [[Category: Schulz | + | [[Category: Schulz C]] |
| - | [[Category: Smith | + | [[Category: Smith WW]] |
| - | [[Category: Tew | + | [[Category: Tew DG]] |
| - | [[Category: Thompson | + | [[Category: Thompson SK]] |
| - | [[Category: Tomazek | + | [[Category: Tomazek Jr TA]] |
| - | [[Category: Veber | + | [[Category: Veber DF]] |
| - | [[Category: Xiong | + | [[Category: Xiong WC]] |
| - | [[Category: Yamamoto | + | [[Category: Yamamoto Y]] |
| - | [[Category: Yamashita | + | [[Category: Yamashita K]] |
| - | [[Category: Yang | + | [[Category: Yang G]] |
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Current revision
Human Methionine Aminopeptidase-2 Complexed with SB-587094
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Categories: Homo sapiens | Large Structures | Fisher PW | Hofmann GA | Janson CA | Johnson RK | Kirkpatrick R | Ma C | Marino Jr JP | Mattern M | Meek TD | Ryan D | Schulz C | Smith WW | Tew DG | Thompson SK | Tomazek Jr TA | Veber DF | Xiong WC | Yamamoto Y | Yamashita K | Yang G
