3tda
From Proteopedia
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==Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6== | ==Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6== | ||
| - | <StructureSection load='3tda' size='340' side='right' caption='[[3tda]], [[Resolution|resolution]] 2.67Å' scene=''> | + | <StructureSection load='3tda' size='340' side='right'caption='[[3tda]], [[Resolution|resolution]] 2.67Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3tda]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3tda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tda OCA], [https://pdbe.org/3tda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tda RCSB], [https://www.ebi.ac.uk/pdbsum/3tda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tda ProSAT]</span></td></tr> |
| - | < | + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref> |
==See Also== | ==See Also== | ||
| - | *[[Cytochrome P450|Cytochrome P450]] | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Johnson | + | [[Category: Johnson EF]] |
| - | [[Category: Stout | + | [[Category: Stout CD]] |
| - | [[Category: Wang | + | [[Category: Wang A]] |
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Current revision
Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6
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