2fep
From Proteopedia
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==Structure of truncated CcpA in complex with P-Ser-HPr and Sulfate ions== | ==Structure of truncated CcpA in complex with P-Ser-HPr and Sulfate ions== | ||
| - | <StructureSection load='2fep' size='340' side='right' caption='[[2fep]], [[Resolution|resolution]] 2.45Å' scene=''> | + | <StructureSection load='2fep' size='340' side='right'caption='[[2fep]], [[Resolution|resolution]] 2.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fep]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2fep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FEP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fep OCA], [https://pdbe.org/2fep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fep RCSB], [https://www.ebi.ac.uk/pdbsum/2fep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fep ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CCPA_BACSU CCPA_BACSU] Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.<ref>PMID:1904524</ref> <ref>PMID:7665492</ref> <ref>PMID:10559165</ref> <ref>PMID:11557150</ref> <ref>PMID:21106498</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fep_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fep_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fep ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Catabolite control protein|Catabolite control protein]] | *[[Catabolite control protein|Catabolite control protein]] | ||
| - | *[[Phosphocarrier protein HPr|Phosphocarrier protein HPr]] | + | *[[Catabolite control protein 3D structures|Catabolite control protein 3D structures]] |
| + | *[[Phosphocarrier protein HPr 3D structures|Phosphocarrier protein HPr 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Chaptal | + | [[Category: Large Structures]] |
| - | [[Category: Deutscher | + | [[Category: Chaptal V]] |
| - | [[Category: Galinier | + | [[Category: Deutscher J]] |
| - | [[Category: Gueguen-Chaignon | + | [[Category: Galinier A]] |
| - | [[Category: Lecampion | + | [[Category: Gueguen-Chaignon V]] |
| - | [[Category: Meyer | + | [[Category: Lecampion C]] |
| - | [[Category: Nessler | + | [[Category: Meyer P]] |
| - | [[Category: Poncet | + | [[Category: Nessler S]] |
| - | + | [[Category: Poncet S]] | |
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Current revision
Structure of truncated CcpA in complex with P-Ser-HPr and Sulfate ions
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