2bmc

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[[Image:2bmc.gif|left|200px]]<br />
 
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<applet load="2bmc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2bmc, resolution 2.60&Aring;" />
 
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'''AURORA-2 T287D T288D COMPLEXED WITH PHA-680632'''<br />
 
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==About this Structure==
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==Aurora-2 T287D T288D complexed with PHA-680632==
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2BMC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MPY as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BMC OCA].
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<StructureSection load='2bmc' size='340' side='right'caption='[[2bmc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2bmc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BMC FirstGlance]. <br>
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[[Category: Transferred entry: 2.7.11.1]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Berta, D.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPY:(3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE'>MPY</scene></td></tr>
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[[Category: Bindi, S.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bmc OCA], [https://pdbe.org/2bmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bmc RCSB], [https://www.ebi.ac.uk/pdbsum/2bmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bmc ProSAT]</span></td></tr>
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[[Category: Cameron, A.D.]]
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</table>
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[[Category: Catana, C.]]
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== Function ==
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[[Category: Fancelli, D.]]
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[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
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[[Category: Forte, B.]]
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== Evolutionary Conservation ==
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[[Category: Giordano, P.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Izzo, G.]]
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Check<jmol>
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[[Category: Mantegani, S.]]
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<jmolCheckbox>
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[[Category: Meroni, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/2bmc_consurf.spt"</scriptWhenChecked>
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[[Category: Moll, J.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pittala, V.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Rusconi, L.]]
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</jmolCheckbox>
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[[Category: Sagliano, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bmc ConSurf].
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[[Category: Severino, D.]]
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<div style="clear:both"></div>
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[[Category: Storici, P.]]
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[[Category: Tonani, R.]]
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[[Category: Varasi, M.]]
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[[Category: Vianello, P.]]
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[[Category: Vulpetti, A.]]
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[[Category: MPY]]
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[[Category: atp-binding]]
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[[Category: cell cycle]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:44:08 2007''
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Berta D]]
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[[Category: Bindi S]]
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[[Category: Cameron AD]]
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[[Category: Catana C]]
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[[Category: Fancelli D]]
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[[Category: Forte B]]
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[[Category: Giordano P]]
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[[Category: Izzo G]]
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[[Category: Mantegani S]]
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[[Category: Meroni M]]
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[[Category: Moll J]]
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[[Category: Pittala V]]
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[[Category: Rusconi L]]
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[[Category: Sagliano A]]
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[[Category: Severino D]]
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[[Category: Storici P]]
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[[Category: Tonani R]]
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[[Category: Varasi M]]
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[[Category: Vianello P]]
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[[Category: Vulpetti A]]

Current revision

Aurora-2 T287D T288D complexed with PHA-680632

PDB ID 2bmc

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OCA

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