4qxu

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==Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody==
==Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody==
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<StructureSection load='4qxu' size='340' side='right' caption='[[4qxu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4qxu' size='340' side='right'caption='[[4qxu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qxu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QXU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qxu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QXU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ouu|4ouu]], [[4p3d|4p3d]], [[4p3c|4p3c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxu OCA], [https://pdbe.org/4qxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qxu RCSB], [https://www.ebi.ac.uk/pdbsum/4qxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qxu RCSB], [http://www.ebi.ac.uk/pdbsum/4qxu PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN]] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref>
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[https://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4qxu" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Membrane-type matrix metalloproteinase-1]]
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[[Category: Homo sapiens]]
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[[Category: Arroyo, A G]]
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[[Category: Large Structures]]
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[[Category: Cuiniasse, P]]
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[[Category: Mus musculus]]
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[[Category: Dive, V]]
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[[Category: Arroyo AG]]
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[[Category: Dym, O]]
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[[Category: Cuiniasse P]]
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[[Category: Grossman, M]]
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[[Category: Dive V]]
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[[Category: ISPC, Israel Structural Proteomics Center]]
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[[Category: Dym O]]
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[[Category: Moreno, v]]
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[[Category: Grossman M]]
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[[Category: Rozenberg, H]]
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[[Category: Moreno v]]
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[[Category: Sagi, I]]
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[[Category: Rozenberg H]]
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[[Category: Solomonov, I]]
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[[Category: Sagi I]]
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[[Category: Udi, Y]]
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[[Category: Solomonov I]]
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[[Category: Igg fold]]
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[[Category: Udi Y]]
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[[Category: Immune system]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Structural genomic]]
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Current revision

Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody

PDB ID 4qxu

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