4wgi

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==A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)==
==A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)==
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<StructureSection load='4wgi' size='340' side='right' caption='[[4wgi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4wgi' size='340' side='right'caption='[[4wgi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WGI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WGI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [http://www.ebi.ac.uk/pdbsum/4wgi PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [https://pdbe.org/4wgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [https://www.ebi.ac.uk/pdbsum/4wgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wgi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wgi" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clifton, M C]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Fairman, J W]]
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[[Category: Homo sapiens]]
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[[Category: Fang, C]]
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[[Category: Large Structures]]
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[[Category: Fulroth, B]]
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[[Category: Clifton MC]]
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[[Category: Golub, T R]]
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[[Category: D'Souza B]]
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[[Category: Hubbard, B K]]
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[[Category: Fairman JW]]
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[[Category: Kaushik, V]]
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[[Category: Fang C]]
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[[Category: Leed, A]]
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[[Category: Fulroth B]]
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[[Category: McCarren, P]]
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[[Category: Golub TR]]
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[[Category: Palmer, M]]
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[[Category: Hubbard BK]]
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[[Category: Serrano-Wu, M H]]
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[[Category: Kaushik V]]
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[[Category: Souza, B D]]
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[[Category: Leed A]]
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[[Category: Wang, L]]
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[[Category: McCarren P]]
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[[Category: Wang, Y]]
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[[Category: Palmer M]]
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[[Category: Wei, G]]
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[[Category: Serrano-Wu MH]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Wang L]]
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[[Category: Fusion protein]]
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[[Category: Wang Y]]
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[[Category: Mbp]]
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[[Category: Wei G]]
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[[Category: Transport protein]]
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[[Category: Transport protein-inhibitor complex]]
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Current revision

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

PDB ID 4wgi

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