4ruh

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'''Unreleased structure'''
 
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The entry 4ruh is ON HOLD until Nov 19 2016
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==Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A==
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<StructureSection load='4ruh' size='340' side='right'caption='[[4ruh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: pandya, V., Kaushik, A., Singh, A.K., Singh, R.P., Kumaran, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ruh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUH FirstGlance]. <br>
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Description: Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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[[Category: Pandya, V]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ruh OCA], [https://pdbe.org/4ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ruh RCSB], [https://www.ebi.ac.uk/pdbsum/4ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ruh ProSAT]</span></td></tr>
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[[Category: Kumaran, S]]
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</table>
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[[Category: Kaushik, A]]
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== Function ==
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[[Category: Singh, R.P]]
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[https://www.uniprot.org/uniprot/CNDP2_HUMAN CNDP2_HUMAN] Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.<ref>PMID:17121880</ref> <ref>PMID:19346245</ref>
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[[Category: Singh, A.K]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kaushik A]]
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[[Category: Kumaran S]]
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[[Category: Singh AK]]
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[[Category: Singh RP]]
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[[Category: Pandya V]]

Current revision

Crystal structure of Human Carnosinase-2 (CN2) in complex with inhibitor, Bestatin at 2.25 A

PDB ID 4ruh

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