2fvv
From Proteopedia
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| - | [[Image:2fvv.gif|left|200px]] | ||
| - | + | ==Human Diphosphoinositol polyphosphate phosphohydrolase 1== | |
| - | + | <StructureSection load='2fvv' size='340' side='right'caption='[[2fvv]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[2fvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVV FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvv OCA], [https://pdbe.org/2fvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvv RCSB], [https://www.ebi.ac.uk/pdbsum/2fvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvv ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/NUDT3_HUMAN NUDT3_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<ref>PMID:9822604</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvv_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvv ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Ehn M]] |
| - | [[Category: Ehn | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hallberg BM]] |
| - | [[Category: Hallberg | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Hogbom M]] |
| - | [[Category: Hogbom | + | [[Category: Holmberg-Schiavone L]] |
| - | [[Category: Holmberg-Schiavone | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Kursula P]] |
| - | [[Category: Kursula | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Ogg D]] |
| - | [[Category: Ogg | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | + | [[Category: Stenmark P]] | |
| - | [[Category: Sagemark | + | [[Category: Sundstrom M]] |
| - | [[Category: Stenmark | + | [[Category: Thorsell AG]] |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Thorsell | + | [[Category: Van den Berg S]] |
| - | [[Category: Weigelt | + | |
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Current revision
Human Diphosphoinositol polyphosphate phosphohydrolase 1
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Edwards A | Ehn M | Flodin S | Graslund S | Hallberg BM | Hammarstrom M | Hogbom M | Holmberg-Schiavone L | Kotenyova T | Kursula P | Nilsson-Ehle P | Nordlund P | Nyman T | Ogg D | Persson C | Sagemark J | Stenmark P | Sundstrom M | Thorsell AG | Weigelt J | Van den Berg S
